There is a strong connection between inflammatory bowel disorders and the subsequent onset of colorectal cancer. The objective of this project is to study the effects of anticancer phytochemical-peptide conjugates on the expression of pro-inflammatory cytokines as well as their cellular and molecular impact on the development of colorectal cancer.
Our peptides can easily be conjugated to a variety of other therapeutic molecules targeting indications beyond oncology as a means to improve their internalization and pharmacological activity in target cells expressing the appropriate receptors. For example, our peptides could be conjugated to:
- Druggable monoclonal antibodies (anti-HER2, anti-EGFR, anti-PD1)
- Antibodies with anticancer molecules (antibody drug conjugates)
- Bispecific antibodies
They may also be suited for other applications to transport nanoparticles or liposomes carrying a therapeutic payload. Finally, these new chemical entities could be administered as a monotherapy or combination therapy with any another agent demonstrating anticancer activity.