Publications scientifiques

Consultez les publications scientifiques des chercheurs de la Chaire de prévention et traitement du cancer. Utilisez les onglets ci-dessous pour chercher des articles par année ou par nom de chercheur sur PubMed.

  1. Rodriguez Torres S, Gresseau L, Benhamida M, Fernandez-Marrero Y, ANNABI B. (2023) Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling. Biomedicines 11(4):1000
  2. Gomez Perez M, Tanasie G, Neree AT, Gonzalez Suarez N, Lafortune C, Paquin J, Marcocci L, Pietrangeli P, ANNABI B, Mateescu MA (2023) P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents.  Amino Acids  (in press)
  1. Kassouri C, Rodriguez Torres S, Gonzalez Suarez N, Duhamel S, ANNABI B. (2022) EGCG Prevents the Transcriptional Reprogramming of an Inflammatory and Immune-Suppressive Molecular Signature in Macrophage-like Differentiated Human HL60 Promyelocytic Leukemia Cells. Cancers 14(20):5065
  2. Gonzalez Suarez N, Fernandez-Marrero Y, Torabidastgerdooei S, ANNABI B. (2022) EGCG Prevents the Onset of an Inflammatory and Cancer-Associated Adipocyte-like Phenotype in Adipose-Derived Mesenchymal Stem/Stromal Cells in Response to the Triple-Negative Breast Cancer Secretome. Nutrients 14(5):1099
  3. Currie JC, Demeule M, Charfi C, Zgheib A, Larocque A, Danalache BA, Ouanouki A, Béliveau R, Marsolais C, ANNABI B (2022) The peptide-drug conjugate TH1902: A new sortilin receptor-mediated cancer therapeutic against ovarian and endometrial cancers.  Cancers  14(8):1877
  4. Demeule M, Charfi C, Currie JC, Zgheib A, Danalache BA, Béliveau R, Marsolais C, ANNABI B (2022) The TH1902 docetaxel peptide-drug conjugate inhibits xenografts growth of cancer stem-like cells derived from human SORT1-positive ovarian and triple-negative breast cancers.  Pharmaceutics  14(9):1910
  5. Gresseau L, Roy ME, Duhamel S, ANNABI B (2022) A signaling crosstalk links Snail to the 37/67 kDa laminin-1 receptor ribosomal protein SA and regulates the acquisition of a cancer stem cell molecular signature in U87 glioblastoma neurospheres.  Cancers  14(23):5944
  6. Pratt J, Haidara K, ANNABI B (2022) MT1-MMP expression levels and catalytic functions dictate LDL receptor-related protein-1 ligand internalization capacity in U87 glioblastoma cells.  International Journal of Molecular Sciences  23(22):14214
  1. Djediai S, Gonzalez Suarez N, El Cheikh-Hussein L, Rodriguez Torres S, Gresseau L, Dhayne S, Joly-Lopez Z, ANNABI B (2021) MT1-MMP Cooperates with TGF-b Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells. International Journal of Molecular Sciences 22(23):13006
  2. Sicard AA, Gonzalez Suarez N, Cappadocia L, ANNABI B (2021) Functional targeting of the TGF- βR1 kinase domain and downstream signaling: A role for the galloyl moiety of green tea-derived catechins in ES-2 ovarian clear cell carcinoma.  Journal of Nutritional Biochemistry 87:108518
  3. Sicard AA, Dao T, Suarez NG, ANNABI B (2021) Diet-Derived Gallated Catechins Prevent TGF-b-Mediated Epithelial-
    Mesenchymal Transition, Cell Migration and Vasculogenic Mimicry in Chemosensitive ES-2 Ovarian Cancer Cells    . Nutrition and Cancer 73(1):169-180
  4. González Suárez N, Rodriguez Torres S, Ouanouki A, El Cheikh-Hussein L, ANNABI B (2021). EGCG inhibits adipose-derived mesenchymal stem cells differentiation into adipocytes and prevents a STAT3-mediated paracrine oncogenic control of triple-negative breast cancer cell invasive phenotype. Molecules 26(6):1506
  5. Uthamacumaran A, Gonzalez Suarez N, Baniré Diallo A, ANNABI B (2021) Machine learning algorithms for the structure-to-function analysis of diet-derived catechins-mediated targeting of in vitro vasculogenic mimicry. Cancer Informatics 20:1-8
  6. Demeule M, Charfi C, Currie JC, Larocque A, Zgheib A, Kozelko S, Béliveau R, Marsolais C, ANNABI B (2021) TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer.  Cancer Science  12(10):4317-4334
  7. Charfi C, Demeule M, Currie JC, Larocque A, Zgheib A, Danalache BA, Ouanouki A, Béliveau R, Marsolais C, ANNABI B (2021) New peptide-drug conjugates for precise targeting of SORT1-mediated vasculogenic mimicry in the tumor microenvironment of TNBC-derived MDA-MB-231 breast and ovarian ES-2 clear cell carcinoma cells.  Frontiers in Oncology:11:760787
  8. Mélin L, Abdullayev S, Fnaiche A, Gonzalez Suarez N, Vu V, Li F, Zeng H, Li F, Senisterra G, Allali-Hassani A, Dong A, Woo S, Halabelian L, Vedadi M, Barsyte-Lovejoy D, ANNABI B, Laplante S, Santhakumar V, Gagnon A (2021) Development of LM98, a small-molecule TEAD inhibitor derived from flufenamic acid. Chem Med Chem 16(19):2982-3002
  9. Hajjar R, Oliero M, Cuisiniere T, Fragoso G, Calvé A, Djediai S, ANNABI B, Richard CS, Santos MM (2021) Improvement of colonic anastomotic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides.  Clinical Nutrition  40(6):3842-3851
  10. Abusarah J, Khodayarian F, El-Hachem N, Salame N, Olivier M, Balood M, Roversi K, Talbot S, Bikorimana JP, Chen J, Jolicoeur M, Trudeau LE, Kamyabiazar S, ANNABI B, Robert F, Pelletier J, El-Kadiry AE, Shammaa R, Rafei M. (2021) Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice. Cell Rep Med. 2(12):100455.
  1. Dao T, Salahuddin S, Charfi C, Sicard AA, Jenabian MA, ANNABI B (2020) Pharmacological targeting of neurotensin response by diet-derived EGCG in macrophage-differentiated HL-60 promyelocytic leukemia cells. PharmaNutrition 12:100191
  2. Martin AC, Tomasin R, Luna-Dulcey L, Graminha AE, Naves MA, Gomes Teles RH, da Silva VD, da Silva JA, Vieira PC, ANNABI B, Cominetti MR (2020) [10]-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models. Cellular Oncology 43(5):915-929
  3. Francisco Fernandez M, Piloto-Ferrer J, ANNABI B. Targeting of Cancer Cell Drug Resistance Phenotype and Metastasis with Xanthium strumarium L. Extract. Trends in Pharmaceutical Research and Development. 2020 vol(3), Print ISBN Number: 978-93-90206-07-0, E ISBN Number: 978-93-90206-08-7
  1. Nanni SB, Pratt J, Beauchemin D, Haidara K, Annabi B. (2016) Impact of Concanavalin-A-Mediated Cytoskeleton Disruption on Low-Density Lipoprotein Receptor-Related Protein-1 Internalization and Cell Surface Expression in Glioblastomas. Biomark Cancer. 19(8) :77-87.
  2. Lamy S, Ben Saad A, Zgheib A, Annabi B. (2016) Olive oil compounds inhibit the paracrine regulation of TNF-a-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression. J Nutr Biochem. 27:136-145.
  3. Pratt J, Iddir M, Bourgault S, Annabi B. (2016) Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma. Mol Carcinog. 55(2):148-60.
  4. Pratt A, Coady M, Annabi B. (2016) Membrane type-1 matrix metalloproteinase-regulated autophagy : A role in brain cancer chemoresistance. Autophagy: Cancer, other pathologies, inflammation, immunity, infection, and aging. vol(10), pp213-230
  1. Lamy S, Moldovan PL, Ben Saad A, Annabi B. (2015) Biphasic effects of luteolin on interleukin-1b-induced cyclooxygenase-2 expression in glioblastoma cells. Biochim Biophys Acta 1853:126-135
  2. Regina A, Demeule M, Tripathy S, Lord-Dufour S, Currie JC, Iddir M, Annabi B, Castaigne JP, Lachowicz JE. (2015) ANG4043, a novel brain-penetrant peptide-mAb conjugate, is efficacious against HER2-positive intracranial tumors in mice. Mol Cancer Ther.14(1):129-40.
  3. Wagner M, Ohlund L, Shiao TC, Vézina A, Annabi B, Roy R, & Sleno L. (2015) Isotope-labeled differential profiling of metabolites using N-benzoyloxysuccinimide derivatization coupled to liquid chromatography/high-resolution tandem mass spectrometry.  Rapid Communications in Mass Spectrometry  29(18):1632-1640
  1. Toufaily C, Charfi C, Annabi B, Annabi B. (2014) A Role for the Cavin-3/Matrix Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype. Cancer Growth Metastasis. 7:43-51.
  2. Gupta R, Toufaily C, Annabi B. Caveolin and cavin family members: dual roles in cancer. Biochimie.107 Pt B:188-202.
  3. Chokor R, Lamy S, Annabi B (2014) Transcriptional targeting of sphingosine-1-phosphate receptor S1P2 by epigallocatechin-3-gallate prevents sphingosine-1-phosphate-mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells. Onco Targets Ther 7:667-677.
  4. Pratt J, Annabi B. (2014) Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. Cell Signal. 26(5):917-24.
  5. Lamy S, Ouanouki A, Béliveau R, Desrosiers RR. (2014) Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation. Exp Cell Res 322(1):89-98.
  6. Demeule M, Beaudet N, Régina A, Besserer-Offroy ÿ, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault ÿ, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P. (2014) Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. J Clin Invest. 2014 Mar;124(3):1199-213.
  7. Desjarlais M, Pratt J, Lounis A, Mounier C, Haidara K, Annabi B (2014) Tetracycline Derivative Minocycline Inhibits Autophagy and Inflammation in Concanavalin-A-Activated Human Hepatoma Cells. Gene Regul Syst Bio. 8:63-73
  8. Vézina A, Vaillancourt-Jean E, Albarao S, Annabi B (2014) Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling. Cancer Lett. 345(1):100-105
  1. Vézina A, Chokor R, Annabi B. (2012) EGCG targeting efficacy of NF-κB downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells. Cancer Immunol Immunother. 61(12):2321-31.
  2. Akla N, Pratt J, Annabi B. (2012) Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells. Exp Cell Res. 318(19):2498-506.
  3. Pratt J, Roy R, Annabi B. (2012) Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Glycobiology. 22(9):1245-55.
  4. Lamy S, Akla N, Ouanouki A, Lord-Dufour S, Béliveau R (2012) Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway. Experimental Cell Research 318:1586-1596
  5. Annabi B, Lord-Dufour S, Vézina A, Béliveau R (2012) Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is Sirt1-independent. Drug Target Insights 2012:6 1-11
  6. Michaud-Levesque J, Bousquet-Gagnon N, Béliveau R (2012) Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration. Exp Cell Res 318(8):925-35.
  7. Sartelet H., Imbriglio T., Nyalendo C., Haddad E., Annabi B., Duval M., Fetni R., Victor K., Alexendrov L., Sinnett D., Fabre M., Vassal G. (2012) CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. Histopathology 60:1144-1155
  1. Bertrand Y, Currie JC, Poirier J, Demeule M, Abulrob A, Fatehi D, Stanimirovic D, Sartelet H, Castaigne JP, Béliveau R (2011) Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein-1. British Journal of Cancer (2011) 105, 1697-1707
  2. Gingras D, Beliveau R (2011). Colorectal cancer prevention through dietary and lifestyle modifications. Cancer Microenvironment 4: 133-139
  3. Proulx-Bonneau S. & Annabi B. (2011) The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells: A role for the secreted Frizzeled-Related Proteins. Biomarker Insights 6:107-118
  4. Proulx-Bonneau S., Pratt J. & Annabi B. (2011) A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells. Journal of Neurooncology 104(1):33-43
  5. Proulx-Bonneau S., Guezguez A. & Annabi B. (2011) A Concerted HIF-1α/MT1-MMP Signalling Axis Regulates the Expression of the 3BP2 Adaptor Protein in Hypoxic Mesenchymal Stromal Cells. PLoS ONE 6(6):e21511
  6. Tahanian T., Arguello-Sanchez L., Shiao TC., Roy R. & Annabi B. (2011)  Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. Drug Design, Development and Therapy 5:299-309
  7. Tahanian E., Peiro S. & Annabi B. (2011) Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells. Journal of Inflammation Research 4(1):1-10
  8. Sina A., Lord-Dufour S., Roy R., & Annabi B. (2011) Ciblage pharmacologique de la MT1-MMP dans les cellules tumorales cérébrales par l’actinonine, un inhibiteur de l’aminopeptidase N/CD13. BioTribune Magazine 38-39(1):12-18
  9. Kuss S., Cornut R., Beaulieu I., Mezour M.A., Annabi B. & Mauzeroll J. (2011) Assessing multidrug resistance protein 1-mediated function in cancer cell multidrug resistance by scanning electrochemical microscopy and flow cytometry. Bioelectrochemistry 82(1):29-37
  1. Perry MC, Demeule M, Régina A, Moumdjian R, Béliveau R (2010) Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Mol. Nutr. Food Res. 2010; 53, 1-10
  2. Ché C, Yang G, Thiot C, Lacoste MC, Currie JC, Demeule M, Régina A, Béliveau R, Castaigne JP (2010) New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration. J. Med. Chem. 2010; 53(7):2814-2824
  3. Annabi B, Doumit J, Plouffe K, Laflamme C, Lord-Dufour S & Béliveau R (2010) Members of the low density lipoprotein receptor-related-proteins provide a differential molecular signature between parental and CD133(+) DAOY medulloblastoma cells Molecular Carcinogenesis 2010:49(7) 710-717
  4. Nyalendo C, Sartelet H, Gingras D, Béliveau R (2010) Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice. Anticancer Research 2010; 30:1887-1896
  5. Lamy S, Lachambre M-P, Lord-Dufour S, Béliveau R (2010) Propranolol suppresses angiogenesis in vitro: inhibition of proliferation, migration, and differentiation of endothelial cells. Vascular Pharmacology 53(2010) 200-208
  6. Annabi B, Vaillancourt-Jean E, Weil AG & Béliveau R (2010) Pharmacological targeting of b-adrenergic receptor functions abrogates carcinogen-mediated MMP-9 secretion through NF-kB signalling in medulloblastoma cells OncoTargets and Therapy 3:219-226
  7. Tahanian E., Lord-Dufour S., Das A., Khosla C., Roy R., & Annabi B. (2010) Inhibition of Tubulogenesis and of Carcinogenmediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog.  Chemical Biology and Drug Design  75(5):481-488
  8. Sina A., Proulx-Bonneau S., Roy A., Poliquin L., Cao J. & Annabi B. (2010) The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKg/NF-kB-dependent pathway.  Journal of Cell Communication and Signaling  4(1):31-38
  1. Annabi B, Lachambre MP, Plouffe K, Sartelet H & Béliveau R (2009) Modulation of invasive properties of CD133(+) glioblastoma stem cells : A role for MT1-MMP in bioactive lysophospholipid signaling Molecular Carcinogenesis 48(10):910-919
  2. Annabi B, Laflamme C, Sina A, Lachambre MP, Béliveau R (2009) A MT1-MMP/NF-kB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells. Journal of Neuroinflammation 6(1):8
  3. Labbé D, Provençal M, Lamy S, Boivin D, Gingras D and Béliveau R (2009) The Flavonols Quercetin, Kaempferol, and Myricetin Inhibit Hepatocyte Growth Factor-Induced Medulloblastoma Cell Migration J. Nutr. 2009;139 646-652
  4. Provençal M, Labbé D, Veitch R, Boivin D, Rivard G-E, Sartelet H, Robitaille Y, Gingras D and Béliveau R (2009) c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration. Carcinogenesis 2009 30: 1089-1096
  5. Gingras D, Béliveau R (2009) Emerging concepts in the regulation of membrane type-1 matrix metalloproteinase activity. Biochim. Biophys. Acta Mol. Cell Res. (in press)
  6. Annabi B, Lachambre MP, Plouffe K, Moumdjian R & Béliveau R (2009) Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion Pharmacological Research 60(5):438-445
  7. Bertrand Y, Currie JC, Demeule M, Régina A, Ché C, Abulrob A, Fatehi D, Sartelet H, Gabathuler R, Castaigne JP, Stanimirovic D, Béliveau R (2009) Transport characteristics of a novel peptide platform for CNS therapeutics. J Cell Mol Med. 2009 Oct 10 (in press).
  8. Provençal M, Labbé D, Veitch R, Boivin D, Rivard GE, Gingras D, Béliveau R (2009) Tissue factor mediates the HGF/MET-induced anti-apoptotic pathway in DAOY medulloblastoma cells. Journal of Neurooncol. 97(3):365-72
  9. Nyalendo C, Sartelet H, Barrette S, Ohta S, Gingras D, Béliveau R (2009) Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression. BMC Cancer 9, 422
  10. Dagenais C, Avdeef A, Tsinman O, Dudley A, Béliveau R (2009) P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model. Eur J Pharm Sci. 2009:38(2):121-137
  11. Boivin D, Labbé D, Fontaine N, Lamy S, Beaulieu E, Gingras D, Béliveau R (2009) The stem cell marker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Src and Fyn tyrosine kinases. Biochemistry. 2009:48(18)3998-4007
  12. Lord-Dufour S., Copland IB., Levros LC., Post M., Das A., Khosla C., Galipeau J., Rassart E. & Annabi B. (2009) Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1a : Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells  27(3):489-497
  13. Sina A., Lord-Dufour S. & Annabi B. (2009) Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Letters  279(2):171-176
  14. Copland IB., Lord-Dufour S., Cuerquis J., Legault-Coutu D., Annabi B., Wang E. & Galipeau J. (2009) Improved autograft survival of mesenchymal stromal cells by plasminogen activator inhibitor 1 inhibition. Stem Cells  27(2):467-477
  1. Provençal M, Michaud M, Beaulieu É, Ratel D, Rivard GE, Gingras D, and Béliveau R (2008) Tissue factor pathway inhibitor interferes with endothelial cell migration by inhibition of both the Erk pathway and proteins involved in focal adhesions. Thromb. Haemost. 99: 576-585
  2. Demeule M, Régina A, Ché C, Poirier J, Nguyen T, Gabathuler R, Castaigne J-P, Béliveau R (2008) Identification and design of peptides as a new drug delivery system for the brain. The Journal of Pharmacology and Experimental Therapeutics. 324(3) 1064-1072.
  3. Annabi B, Rojas-Sutterlin S, Laflamme C, Lachambre MP, Rolland Y, Sartelet H & Béliveau R (2008) Tumor Environment Dictates Medulloblastoma Cancer Stem Cell Expression and Invasive Phenotype. Molecular Cancer Research 6: p. 907-916
  4. Lamy S, Beaulieu E, Labbé D, Bédard V, Moghrabi A, Barrette S, Gingras D, Béliveau R (2008) Delphinidin, a dietary anthocyanidin, inhibits platelet derived growth fator ligand/receptor (PDGF/PDGFR) signaling. Carcinogenesis. 29(5) 1033-1041
  5. Barakat S, Turcotte S, Demeule M, Lachambre MP, Régina A, Baggetto LG, Béliveau R (2008) Regulation of Brain Endothelial Cells Migration and Angiogenesis by P-glycoprotein/Caveolin-1 Interaction. Biochemical Biophysical Research Communications. 372(3) 440-446
  6. Régina A, Demeule M, Ché C, Lavallée I, Poirier J, Gabathuler R, Béliveau R, Castaigne JP (2008) Antitumor activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. British Journal of Pharmacology. 155(2) 185-197
  7. Demeule M, Currie JC, Bertrand Y, Ché C, Nguyen T, Régina A, Gabathuler R, Castaigne JP, Béliveau R (2008) Involvement of the low-density lipoprotein receptor related protein in the transcytosis of the brain delivery vector Angiopep-2. Journal of Neurochemistry. 106(4) 1534-1544
  8. Nyalendo C, Beaulieu É, Sartelet H, Michaud M, Fontaine N, Gingras D, and Béliveau R (2008) Impaired tyrosine phosphorylation of membrane type-1 matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice. Carcinogenesis. 29(8) 1655-1664
  9. Boivin D, Lamy S, Lord-Dufour S, Jackson J, Beaulieu E, Côté M, Moghrabi A, Barrette S, Gingras D, Béliveau R (2008) Antiproliferative and antioxidant activities of common vegetables: A comparative study. Food Chemistry. 112(2009) 374-380
  10. Lamy S, Bédard V, Sartelet H, Barthomeuf C, Gingras D, Béliveau R (2008) The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-? phosphorylation. Cancer Prev. Res. 2008;1(6) November 2008
  11. Rolland Y, Demeule M, Fenart L, Béliveau R (2008) Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface. Pigment Cell Melanoma Res. 22: 86-98
  12. Fortier S., Labelle D., Sina A., Moreau R. & Annabi B. (2008) Silencing of the MT1-MMP / G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.  FEBS Letters  582(5):799-804
  13. Fortier S., Touaibia M., Lord-Dufour S., Galipeau J., Roy R. & Annabi B. (2008) Tetra- and hexavalent mannosides inhibit the pro-apoptotic, anti-proliferative and cell surface clustering effects of concanavalin-A : Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells.  Glycobiology  18(2):195-204
  14. Annabi B., Rojas-Sutterlin S., Laroche M., Lachambre MP., Moumdjian R. & Béliveau R. (2008) The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis.  Molecular Nutrition and Food Research  52(6):692-700
  15. Copland IB., Jolicoeur ME., Gillis MA., Cuerquis J., Eliopoulos N., Annabi B., Calderone A., Tanguay JF., Ducharme A. & Galipeau J. (2008) Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties.  Cardiovascular Research  79(3):405-415
  16. Rafei M., Hiseh J., Fortier S., Li M, Yuan S., Birman E., Forner K., Boivin MN., Doody K, Tremblay M., Annabi B. & Galipeau J. (2008) Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood  112(13):4991-4998
  1. Boivin D, Blanchette M, Barrette S, Moghrabi A and Béliveau R (2007) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkB by edible berry juice. Anticancer Research 27(2):937-948.
  2. Langlois S, Nyalendo C, Di Tomasso G, Labrecque L, Roghi C, Murphy G, Gingras D and Béliveau R (2007) Membrane-type 1 Matrix Metalloproteinase Stimulates Cell Migration through Epidermal Growth Factor Receptor Transactivation. Mol. Cancer Res. 2007; 5(6):569-583.
  3. Nyalendo C, Michaud M, Beaulieu E, Roghi C, Murphy G, Gingras D and Béliveau R(2007) Src-dependent phosphorylation of membrane-type 1 matrix metalloproteinase on cytoplasmic tyrosine 573 : Role in endothelial and tumor cell migration. J. Biol. Chem.282(21) : 15690-15699.
  4. Ratel D, Mihoubi S, Beaulieu E, Durocher Y, Rivard GE, Gingras D and Béliveau R (2007) VEGF increases the fibrinolytic activity of endothelial cells within fibrin matrices: Involvement of VEGFR-2, tPA and matrix metalloproteinases. Thrombosis Research 121(2):203-212
  5. Rolland Y, Demeule M, Michaud-Levesque J and Béliveau R (2007) Inhibition of tumor growth by a truncated and soluble form of melanotransferrin. Experimental Cell Research 313 (2007) 2910-2919.
  6. Bertrand Y, Demeule M, Michaud-Levesque J and Béliveau R (2007) Melanotransferrin induces human melanoma SK-Mel-28 cell invasion in vivo. Biochem Biophys Res Commun 353 (2) 418-423.
  7. Béliveau R and Gingras D (2007) The role of nutrition in cancer prevention. Canadian Family Physician. 53(11):1905-1911
  8. Michaud-Levesque J, Demeule M and Béliveau R (2007) Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II. Biol. Chem. 388 (7) 747-754.
  9. Gingras D and Béliveau R (2007). Towards a global assessment of the anticancer properties of fruits and vegetables: The Montreal anticancer nutrinome project. Acta Hort. 744, 157-164.
  10. Desrosiers RR, Beaulieu E, Buchanan M and Béliveau R (2007) Proteomic analysis of human plasma proteins by two-dimensional gel electrophoresis and by antibody arrays following depletion of high abundance proteins. Cell Biochem. and Biophysics. 2007; 49(3):182-195.
  11. Lim S, Grassi J, Akhmedjanova V, Debiton E, Balansard G, Béliveau R and Barthomeuf C (2007) Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum  perforatum Kar. et Kir. and cytotoxicity pattern versus diphyllin, epi-podophyllotoxine and etoposide. Planta Medica. 2007; 73: 1563-1567
  12. Gingras D, Michaud M, Di Tomasso G, Béliveau E, Nyalendo C, and Béliveau R(2007) Sphingosine-1-phosphate induces the interaction of membrane type-1 matrix metalloproteinase with p130Cas in endothelial cells. FEBS Lett. 582 (2008) 399-404
  13. Currie JC., Fortier S., Sina A., Galipeau J., Cao J. & Annabi B. (2007) MT1-MMP down-regulates the glucose-6-phosphate transporter expression in marrow stromal cells : A molecular link between proMMP-2 activation, chemotaxis and cell survival.  Journal of Biological Chemistry  282(11):8142-8149
  14. Belkaid A., Fortier S., Cao J. & Annabi B. (2007) Necrosis induction in glioblastoma cells reveals a new “bioswitch” function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus death cell decision.  Neoplasia  9(4):332-340
  15. Annabi B., Currie JC., Moghrabi A. & Béliveau R. (2007) Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg.  Leukemia Research  31(9):1285-1292
  16. Perri SR., Annabi B. & Galipeau J. (2007) Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton.  FASEB Journal  21(14):3928-3936
  17. Rafei M., Wu JH., Annabi B., Lejeune L., François M. & Galipeau J. (2007) A GMCSF & IL15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.  Blood  109(5):2234-2242
  18. Ngameni B., Touaibia M., Belkaid A., Ambassa P., Watchueng J., Patnam R., Ngadjui BT., Annabi B. & Roy R. (2007) Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.  ARKIVOC – Archive for Organic Chemistry  9:91-103
  1. McLaughlin N, Annabi B, Bouzeghrane M, Temme A, Bahary JP, Moumdjian R and Béliveau R (2006) The survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (-) epigallocatechin-3-gallate. Brain Research. 1071 (2006) 1-9.
  2. Lamy S, Blanchette M, Michaud-Levesque J, Lafleur R, Durocher Y, Moghrabi A, Barrette S, Gingras D, Béliveau R (2006) Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. Carcinogenesis2006 May;27 (5):989-996.
  3. Annabi B, Bouzeghrane M, Currie JC, Dulude H, Daigneault L. Garde S, Rabbani SA, Panchal C, Wu JJ and Béliveau R (2006) The inhibition of MMP-9 secretion by anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptors signalling. Anti-cancer Drugs 17(4): 429-438.
  4. McLaughlin N, Annabi B, Lachambre MP, Kim HS, Bahary JP, Moumdjian R and Béliveau R (2006) Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death. Journal of Neurooncology 80(2):111-121.
  5. Rolland Y, Demeule M and Béliveau R (2006) Melanotransferrin stimulates t-PA-dependent activation of plasminogen in endohelial cells leading to cell detachment. Biochim Biophys Acta1763(2006) 393-401.
  6. Annabi B, Currie JC, Bouzeghrane M, Dulude H, Daigneault L, Garde S, Rabbani SA, Panchal C, Wu JJ & Béliveau R (2006) Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding. Biochemical and Biophysical Research Communications 346(1):358-66.
  7. Barthomeuf C, Demeule M, Grassi J, Saidkhodjaev A and Béliveau R (2006) Conferone from Ferula Schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport. Planta Med. 2006 Jun; 72(7):634-9.
  8. Lamy S, Lafleur R, Bédard V, Moghrabi A, Barrette S, Gingras D and Béliveau R (2006) Anthocyanidins inhibit migration of glioblastoma cells : structure-activity relationship and involvement of the plasminolytic system. J. Cell. Biochem. 100:100-111 (2007).
  9. Michaud-Levesque J, Demeule M and Béliveau R (2006) In vivo inhibition of angiogenesis by a soluble form of melanotransferrin. Carcinogenesis. 28(2):280-288 (2007).
  10. Barakat S, Demeule M, Pilorget A, Régina A, Gingras D, Baggetto LG and Béliveau R (2006) Modulation of P-glycoprotein function by Caveolin-1 Phosphorylation. Journal of Neurochemistry. 101(1):1-8 (2007).
  11. Bertrand Y, Demeule M, Rivard GE and Béliveau R (2006) Stimulation of tPA-dependent provisional extracellular fibrin matrix degradation by melanotransferrin. Biochim Biophys Acta1763(2006):1024-1030.
  12. Béliveau R, Gingras D (2006) Can foods combat cancer ? Arresting malignancies with diet. Oncology Exchange 5(3):31-34 Jul 2006.
  13. McLaughlin N, Annabi B, Kim HS, Bahary JP, Moumdjian R & Béliveau R (2006) The response to brain tumor-derived growth factors is altered in radioresistant human brain endothelial cells. Cancer Biology & Therapy 5(11):1539-1545.
  14. Annabi B, Currie JC, Moghrabi A and Béliveau R (2007) Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg Leukemia Research 31(9):1285-1292.
  15. Pilorget A, Demeule M, Barakat S, Marvaldi J, Luis J and Béliveau R (2006) Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. Journal of Neurochemistry (2007) 100, 1203-1210.
  16. Pilorget A, Conesa M, Sarray S, Michaud-Levesque J, Daoud S, Kim KS, Demeule M, Marvaldi J, El Ayeb M, Marrakchi N, Béliveau R and Luis J (2006) Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits both in vitro and in vivo angiogenesis. Journal of Cellular Physiology 211:207-315, 2007.
  17. Ngameni B., Touaibia M., Patnam R., Belkaid A., Sonna P., Bonaventure T. Ngadjui BT., Roy R. & Annabi B. (2006) Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata.  Phytochemistry  67(23):2573-2579
  18. Lamy S., Ruiz M., Wisniewski J., Garde S., Panchal C., Rabbani SA., Wu JJ. & Annabi B. (2006) A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis.  International Journal of Cancer  118(9):2350-2358
  19. Desrosiers RR., Rivard ME., Grundy P. & Annabi B. (2006) Decrease in LDL receptor-related protein expression and function correlates with advanced stages and anaplastic phenotypes of Wilms tumors.  Pediatric Blood & Cancer  46(1):40-49
  20. Belkaid A., Currie JC., Desgagnés J. & Annabi B. (2006) The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression.  Cancer Cell International  6(1):7
  21. Belkaid A., Copland IB., Massillon D. & Annabi B. (2006) Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: Potential new anticancer target for curcumin.  FEBS Letters  580(15):3746-3752
  22. Meriane M., Duhamel S., Lejeune L., Galipeau J. & Annabi B. (2006) Cooperation of Matrix Metalloproteinases with the RhoA/Rho Kinase and Mitogen-Activated Protein Kinase Kinase-1/Extracellular Signal-Regulated Kinase Signaling Pathways Is Required for the Sphingosine-1-Phosphate-Induced Mobilization of Marrow-Derived Stromal Cells.  Stem Cells  24(11):2557-276
  1. Desrosiers RR, Cusson MH, Turcotte S and Béliveau R (2005) The farnesyltransferase inhibitor SCH-66336 down-regulates secretion of matrix proteinases and inhibits carcinoma cell migration. Int. J Cancer 114:702-712.
  2. Labrecque L, Nyalendo C, Langlois S, Durocher Y, Roghi C, Murphy G, Gingras D, Béliveau R (2004) Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane-type-1 matrix metalloproteinase. J Biol Chem 279:52132-52140.
  3. Demeule M, Annabi B, Michaud-Lévesque J, Lamy S and Béliveau R (2005) Dietary prevention of cancer: Anticancer and Antiangiogenic Properties of Green Tea Polyphenols. Medicinal Chemistry Reviews2:49-58.
  4. Michaud-Lévesque J, Rolland Y, Demeule M, Bertrand Y and Béliveau R (2005) Inhibition of endothelial cells migration and tubulogenesis by exogenous human recombinant soluble melanotransferrin: involvement of the uPAR/LRP plasminolytic system. Bioch. Biophys. Acta. 1743 (243-253).
  5. Ratel D, Glazier G, Provençal M, Boivin D, Beaulieu E, Gingras D, and Béliveau (2005) Direct-acting fibrinolytic enzymes in shark cartilage extract: Potential therapeutic role in vascular disorders. Thrombosis Res. 115:143-152.
  6. Labrecque L, Lamy S, Chapus A, Mihoubi S, Durocher Y, Cass B, Bojanowski MW, Gingras D and Béliveau R (2005) Combined inhibition of PDGF end VEGF receptors by ellagic acid, a dietary-derived phenolic compound. Carcinogenesis 26:821-826.
  7. Barthomeuf C, Grassi J, Demeule M, Fournier C, Boivin D and Béliveau R (2005) Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. Cancer Chemotherapy and Pharmacology. 56:173-181.
  8. Langlois S, Di Tomasso G, Boivin D, Roghi C, Murphy G, Gingras D and Béliveau R (2005) Membrane type 1-matrix metalloproteinase induces endothelial cell morphogenic differentiation by a caspase-dependent mechanism. Exp. Cell Res. 307:452-464.
  9. Annabi B, Bouzeghrane M, Moumdjian R, Moghrabi A and Béliveau R (2005) Probing the infiltrating character of brain tumors : Inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg. Journal of Neurochemistry 94:906-916.
  10. Pilorget A, Annabi B, Bouzeghrane M, Marvaldi J, Luis J and Béliveau R (2005) Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. Journal of Cerebral Blodd Flow & Metabolism 25:1171-1182.
  11. Caron A, Desrosiers RR, Langlois S and Béliveau R (2005) Ischemia-reperfusion injury stimulates gelatinase expression and activity in kidney glomeruli. Can. J. Physiol. Pharmacol. 83:287-300.
  12. Perri SR, Nalbantoglu J, Annabi B, Koty Z, Lejeune L, François M, Di Falco MR, Béliveau R and Galipeau J (2005) Plasminogen Kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vasulatization and progression. Cancer Research. 65:8359-8365.
  13. Annabi B., Bouzeghrane M., Currie JC., Hawkins R., Dulude H., Daigneault L., Ruiz M.,Wisniewski J., Garde S., Rabbani SA., Panchal C., Wu JJ. & Béliveau R (2005) A PSP-derived synthetic peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding : Implications in tumor metastasis. Clinical & Experimental Metastasis 22:429-439.
  14. Barthomeuf C, Lamy S, Blanchette M, Boivin D, Gingras D and Béliveau R (2005) Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a down-regulation of PAF synthesis. Free Rad. Biol. Med. 40 (2006) 581-590.
  15. Caron A, Desrosiers RR and Béliveau R (2005) Ischemia injury alters endothelial properties of kidney cortex: Stimulation of MMP-9. Exp. Cell Res. 310:105-116.
  16. El Hader C, Tremblay S, Solban N, Gingras D, Béliveau R, Orlov S N, Hamet P and Tremblay J (2005) HcaRG increases renal cell migration by an internal TGF-a autocrine loop mechanism. Am J Physiol 289:F1273-80.
  1. Régina A, Jodoin J, Khoueir P, Rolland Y, Berthelet F, Moumdjian R, Fenart L, Cecchelli R, Demeule M and Béliveau R (2004) Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy. J Neurosci. Res. 75:291-299.
  2. Gingras D, Labelle D, Carine N, Boivin D, Demeule M, Barthomeuf C and Béliveau R (2004) The antiangiogenic agent Neovastat (AE-941) stimulates tissue plasminogen activator activity. Invest. New drugs. 22:17-26.
  3. Turcotte S, Desrosiers RR and Béliveau R (2004) Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma. Am J Physiol Renal Physiol. 286:F338-F348.
  4. Gingras D, Gendron M, Boivin D, Moghrabi A, Théoret Y and Béliveau R (2004) Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett. 203:35-43.
  5. Langlois S, Gingras D and Béliveau R (2004) Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphegenic differentiation. Blood 103:3020-3028.
  6. Annabi B, Thibeault S, Moumdjian R and Béliveau R (2004) Hyaluronan cell surface binding Is induced by type I collagen and regulated by caveolae in glioma cells J. Biol. Chem., 279: 21888 – 21896.
  7. Gingras D, Nyalendo C, Di Tomasso G, Annabi B and Béliveau R (2004) Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent. Biochem. Biophys. Res Commun. 320:205-212.
  8. Lacourcière Y, Béliveau R, Conter HS, Burgess ED, Lepage S, Pesant Y, Spence JD, Asmar R, Carrière S, Plante GE (2004) Canadian Hypertension Society. Effects of perindopril on elastic and structural properties of large arteries in essential hypertension. Can J Cardiol 20(8):795-799.
  9. Béliveau R and Gingras D (2004) Green tea: prevention and treatment of cancer by nutraceuticals. Lancet364:1021-2.
  10. Turcotte S, Desrosiers RR, Brand G and Béliveau R (2004) Hypoxia upregulates von Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation. Int. J. Cancer 112: 777-786.
  11. Demeule M, Regina A, Annabi B, Bertrand Y, Bojanowky and Béliveau R (2004) Brain endothelial cells as pharmacological targets in brain tumors. Mol Neurobiol. 30:157-184.
  12. Laplante I, Béliveau R, Paquin J (2004) RhoA/ROCK and Cdc42 regulate cell-cell contact and N-cadherin protein level during neurodetermination of P19 embryonal stem cells. J Neurobiol 60:289-307.
  13. Demeule M, Brossard M, Turcotte S, Regina A, Jodoin J, Béliveau R (2004) Diallyl dusulfide a chemopreventive agent in garlic induces multidrug-resistance associated protein 2 expression Biochem Biophys Res Comm 324: 937-945.
  14. Caron A, Desrosiers RR, Béliveau R (2004) Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules. Arch Biochem Biophys 431:31-46.
  15. Boivin D, Provençal M, Gendron S, Ratel D, Demeule M, Gingras D, and Béliveau R (2004) Purification and characterization of a stimulator of plasmin generation from the antiangiogenic agent Neovastat: identification as immunoglobulin Kappa light chain. Arch. Biochem. Biophys. 431 :197-206.
  16. Barthomeuf C, Boivin D, Béliveau R (2004) Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of Ha-Ras/MEK/ERK cascade. Cancer Chemother Pharmacol. 54:432-440.
  17. Annabi B., Naud E., Lee YT., Eliopoulos N. & Galipeau J. (2004) Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors.  Journal of Cellular Biochemistry  91(6):1146-1158